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Worrying about Children's Height? Growth Hormone Injection vs Precocious Puberty Shots for Delaying Maturity! Exposing the Differences and Safety Risks!

Updated: Mar 11

In contemporary society, height and developmental issues have always been a concern, especially during childhood and adolescence. To address these concerns, people often hear about two medications: growth hormone injections and precocious puberty shots. However, there are significant differences between these two injections, and their safety considerations must also be taken into account."


长高针 vs 早熟针

In contemporary society, height and developmental issues have always been a concern, especially during childhood and adolescence. To address these concerns, people often hear about two medications: growth hormone injections and precocious puberty shots. However, there are significant differences between these two injections, and their safety considerations must also be taken into account.



Growth Hormone Injections, also known as somatropin, are medications used to promote growth and development in children and adolescents. Growth hormone is an essential hormone produced by the body, starting during embryonic development and continuing throughout life. During adolescence, blood levels of growth hormone peak, then decrease by half every seven years, reaching only 1/6 of adolescent levels by age 55. Growth hormone is secreted by the anterior pituitary gland and circulates through the bloodstream to organs with growth hormone receptors throughout the body, primarily acting on bones, muscles, and fat. It promotes bone growth, increases bone density, enhances muscle mass, and facilitates fat metabolism, reducing fat mass. Insufficient secretion of growth hormone in children may manifest as growth retardation and short stature, while adults may experience fatigue, reduced muscle mass, osteoporosis, increased visceral fat, central obesity, and are prone to metabolic syndrome and cardiovascular diseases. Excessive secretion of growth hormone in children can result in rapid growth due to unclosed growth plates, known as "gigantism." In adults, excessive secretion of growth hormone manifests as "acromegaly."


Growth hormone injections are commonly used to treat various growth and developmental issues, including growth hormone deficiency. The mechanism of action of growth hormone injections is to stimulate bone growth by targeting the growth plates, thereby promoting height increase. This treatment method is usually safe when used under medical supervision, and in some cases where it is genuinely needed, it can provide significant results. With regular medical supervision and the correct dosage regimen, growth hormone injections can help patients reach their growth potential. However, misuse of growth hormone injections can lead to a range of adverse effects, including but not limited to bone deformities, metabolic disturbances, and other health issues. Therefore, anyone interested in growth hormone therapy should undergo treatment under close medical supervision and strictly follow the doctor's advice and prescription.


Growth hormone is an important protein hormone composed of 190 amino acids and plays a crucial role in promoting growth and development in children and adolescents. Currently, subcutaneous injection is approved by the FDA as an effective treatment method. This treatment method is highly regarded, in part because the half-life of growth hormone is extremely short, only 14 minutes, so the ideal treatment frequency is to inject once before bedtime every day, which can mimic the secretion of growth hormone under natural physiological conditions. In addition, subcutaneous injection is simple and convenient, with small and short needle lengths, making the injection process almost painless. Furthermore, some products even utilize a concealed needle design, further reducing children's fear of injections. Due to these advantages, the response of both parents and children to actual treatment is generally positive. In fact, many children in upper primary school grades or above can even administer the injections themselves, demonstrating the convenience and safety of subcutaneous injections in the treatment process.


Research has shown that the timing of growth hormone therapy initiation, duration of treatment, and adherence to medical advice are closely related to height prognosis. The earlier the treatment starts, the longer the duration, and the better the adherence to medical advice, the better the expected height increase. Conversely, if treatment is initiated at an older age, with a higher bone age and smaller growth plate space, higher doses of growth hormone and higher treatment costs may be required, but the height increase achieved may be limited. Therefore, once a child is found to be below the third percentile in height, has less than a 4 cm height increase in a year, or has a height curve crossing two percentile curves, they should be promptly taken to a pediatric endocrinologist for proper diagnosis and early treatment.



Precocious Puberty Shots, on the other hand, are medications used to delay early onset of puberty. Precocious puberty shots are a specific medication designed to delay the process of early puberty in children. In cases where early puberty occurs in children, sex hormones may be released prematurely, leading to premature physical and psychological maturity. This excessive secretion of sex hormones may have a negative impact on the child's physical and psychological health, including premature bone maturation, development of secondary sexual characteristics, and emotional stability. Therefore, the main function of precocious puberty shots is to suppress the secretion of sex hormones to delay the process of sexual development, allowing children to reach sexual maturity at a more appropriate time.

Generally, the use of precocious puberty shots requires medical supervision, and doctors will determine whether precocious puberty shots are needed and the specific treatment plan and dosage based on the child's specific situation and medical history. For patients who truly need precocious puberty shots, this treatment plan is usually relatively safe and effective. However, like any medication, overuse of precocious puberty shots can lead to a range of adverse effects. Overuse of precocious puberty shots may result in hormonal imbalances, growth suppression, and even other health issues. Therefore, when deciding to undergo precocious puberty shot treatment, it must be strictly followed under the guidance of a doctor, with regular follow-up visits and monitoring to ensure the safety and effectiveness of the treatment, while minimizing potential risks.


In discussing the safety of growth hormone injections and precocious puberty shots, it is crucial to emphasize the importance of proper use and medical supervision. These medications are not suitable for everyone, and should only be considered when a doctor specifically recommends them based on the patient's individual circumstances. For example, growth hormone injections are typically recommended for individuals with growth hormone deficiency, while precocious puberty shots are suitable for cases requiring the delay of early onset of puberty. Furthermore, long-term use of these medications may pose potential risks, including but not limited to bone deformities and hormonal imbalances, and in some extreme cases, may even affect life and health.



Therefore, we must carefully weigh the pros and cons. When deciding to use these medications, it is important to fully understand their mechanisms of action, side effects, and potential risks, and undergo treatment under medical guidance. Doctors can formulate the most appropriate treatment plan based on the patient's individual situation and medical history, with regular monitoring and adjustments. Only by strictly following medical advice can these medications maximize their effectiveness while ensuring the patient's health and providing a conducive environment for growth and development.

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